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Along the Mississippi, the village of Trempealeau is a lovely river town with a picturesque Main Street listed on the National Register of Historic Places. Visitors can watch river traffic lock-through at Lock & Dam #6. Perrot State Park, two miles northwest of Trempealeau, features 500-foot bluffs with panoramic views of the river valley. A bit further up-river, the Trempealeau National Wildlife Refuge includes a large prairie and miles of nature trails among the Mississippi backwaters that are perfect for bird watching.

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